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¹ Animal Science Department, Adekunle Ajasin University, Akungba Akoko, Nigeria DOI : 10.46897/livestockstudies.1323784 - The objective of this study is to evaluate the nutraceutical values of the leaf of Tapinanthus globiferus hosted by the neem tree. The phytochemical composition, antioxidant activities, antidiabetic properties, anti-inflammatory capabilities, and proximate composition of the Tapinanthus globiferus leaf powder (TLP) were examined. The results revealed the phytochemical profiles: phenol (501.51 mg/g), alkaloids (408.25 mg/g), saponins (7.16 mg/g), steroids (7.16 mg/g), flavonoids 933.79 mg/g) and tannins (86.53 mg/g); antioxidant assay results: Ferrous chelating activity (51.17%), hydroxyl radical inhibition (55.96%), ABTS (76.09%), DPPH (71.34%) and lipid oxidation inhibition (66.18%); antidiabetic assay results: the α-glucosidase inhibition (75.88%) and α- amylase inhibition (72.14 %); anti-inflammatory assays: antiproteinase activity (72.38%) and albumin denaturation inhibition (44.67%) of TLP. Tapinanthus globiferus leaf powder has nitrogen-free extract content of 36.09%, 18.47% crude protein, 13.27% moisture, 12.78% ash, 9.44% crude fibre, and 9.93% crude fat. These findings indicated that TLP had anti-inflammatory, anti-diabetic, and antioxidant properties. Keywords : Anti-oxidant properties Anti-inflammatory Anti-diabetic Mistletoe Phytogenic supplements