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¹ Ankara Üniversitesi Veteriner Fakültesi, Zootekni Anabilim Dalı, Ankara - Hereditary diseases cause significant economic losses like other diseases. The diagnosis of hereditary diseases is not easy. However, with the development of genetic technologies in recent years new genetic disorders can be discovered. One of these diseases is a hereditary disorder called Cholestrol Deficiency (CD), discovered in 2015. Homozygous recessive calves have chronic diarrhea, developmental deficits, and susceptibility to secunder diseases such as pneumonia is increasing. The sick animals do not respond to treatment and die between 3 weeks and 6 months of age. In this article, it is aimed to give detailed information about hereditary CD disease in order to inform veterinarians and breeders. Keywords : Cattle, Holstein, Hereditary Disease, Cholestrol Deficiency