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¹ Hayvancılık Merkez Araştırma Enstitü Müdürlüğü, Lalahan, Ankara
² Ankara Üniversitesi, Veteriner Fakültesi, Genetik AD, Ankara - Aging in mammals causes to loose ovarian functions. The main marker of productivity is vast of primordial follicle pool and lifetime of this pool. Vast of follicle and functions are affected by many factors. Even this complicated mechanism is not understood exactly for determination of reproductive age some transcription factors have an effective role. In this review, transcription factors that have been studied and have an effect on follicular activation will be dealt with and mechanism of follicular activation will be clarified. Keywords : Folliculogenesis, transcription factors, ovarium, oocyte